ABSTRACT
Devido a constante busca por um sorriso harmônico, o nível de exigência e a expectativa dos pacientes tornam-se elevados, propiciando o desenvolvimento de novos materiais e técnicas odontológicas que visam procedimentos mais conservadores e resultados cada vez mais previsíveis esteticamente. As técnicas com Computer Aided Design and Computer Aided Manufacturing (CAD/CAM) têm ocupado lugar de destaque na Odontologia. Isso se deve ao fato de que o projeto auxiliado por computador ou fabricação assistida por computador oferece um método de restauração que diminui o risco de erro humano e fornece resultados altamente estéticos em um tempo clínico reduzido, embora com custos relativamente altos. O objetivo do presente estudo é apresentar, através de um relato de caso clínico, uma reabilitação estética por meio da aplicação prática do sistema CAD / CAM. Com a finalização do caso foi possível observar melhora estética através da confecção das coroas cerâmicas anteriores e melhora da condição oclusal com a confecção de prótese removível superior, a qual viabiliza uma maior durabilidade das coroas cerâmicas, pois distribui melhor as cargas oclusais entre os elementos, evitando cargas excessivas no local das novas restaurações indiretas. Este relato de caso foi realizado em duas sessões odontológicas alcançando satisfação estética da paciente. Possui um acompanhamento de curto prazo, portanto, são necessários casos com acompanhamento a longo prazo para comprovar o sucesso dessa técnica. Pode-se considerar uma limitação o elevado custo tecnológico, porém é notório avanço na odontologia para melhorar a qualidade no tratamento em períodos extremamente curtos.
Due to the constant search for a harmonic smile, the level of demand and the expectations of patients become high, enabling the development of new materials and dental techniques that aim at more conservative procedures and more and more predictable results aesthetically. Techniques with Computer Aided Design and Computer Aided Manufacturing (CAD / CAM) have occupied a prominent place in Dentistry. This is due to the fact that computer aided design or computer aided manufacturing offers a restoration method that lowers the risk of human error and provides highly aesthetic results in a reduced clinical time, albeit at relatively high costs. The objective of the present study is to present, through a clinical case report, an aesthetic rehabilitation through the practical application of the CAD / CAM system. With the completion of the case, it was possible to observe aesthetic improvement through the preparation of the anterior ceramic crowns and improvement of the occlusal condition with the manufacture of a removable upper prosthesis, which enables greater durability of the ceramic crowns, as it better distributes the occlusal loads among the elements, avoiding excessive loads at the site of new indirect restorations. This case report was carried out in two dental sessions, achieving patient aesthetic satisfaction. It has a short-term follow-up, therefore, cases with long-term follow- up are necessary to prove the success of this technique. The high technological cost can be considered a limitation, but there is a notable advance in Dentistry to improve the quality of treatment in extremely short periods.
ABSTRACT
Erythropoietin (EPO) has been well characterized as a renal glycoprotein hormone regulating red blood cell production by inhibiting apoptosis of erythrocyte progenitors in hematopoietic tissues. EPO exerts regulatory effects in cardiac and skeletal muscles. Duchenne muscular dystrophy is a lethal degenerative disorder of skeletal and cardiac muscle. In this study, we tested the possible therapeutic beneficial effect of recombinant EPO (rhEPO) in dystrophic muscles in mdx mice. Total strength was measured using a force transducer coupled to a computer. Gene expression for myostatin, transforming growth factor-β1 (TGF-β1), and tumor necrosis factor-α (TNF-α) was determined by quantitative real time polymerase chain reaction. Myostatin expression was significantly decreased in quadriceps from mdx mice treated with rhEPO (rhEPO=0.60±0.11, control=1.07±0.11). On the other hand, rhEPO had no significant effect on the expression of TGF-β1 (rhEPO=0.95±0.14, control=1.05±0.16) and TNF-α (rhEPO=0.73±0.20, control=1.01±0.09). These results may help to clarify some of the direct actions of EPO on skeletal muscle.